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Establish the EU at the forefront of global xenotransplantation research, a field with huge potential for the treatment of end-stage organ failure. At the end of the programme, the project aims to deliver a European “product” for xenotransplantation. |
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Generate in vivo efficacy data and provide experimental evidence that “engineered” pigs, combined with new immunosuppressive reagents, allow long-term survival of porcine organs transplanted in non human primates. |
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Assess new immunosuppressive regimens and agents for efficient inhibition of immunological rejection. Gain an understanding of the physiology of long-term transplanted xenografts in primate recipients. |
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Establish the necessary safety framework to allow progression of xenotransplantation to the clinic |
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Provide a strong ethical, social, educational through direct engagement of the public) and regulatory framework for Xenotransplantation. |